Chromatography Simulations For Process Developers

Secure cloud-based chromatography modeling, right in your browser. Move smarted and faster with simulations.

Shorten time to milestones

Lower cost and risk

Improve yield and efficiency

Interactive Demo

This is an interactive demo. Full version offers complete control over all process parameters, system settings, column properties, and much more. Learn more

How It Works

1

Set the scope

Define what you want to achieve. Typically, this would be process development, scale up studies, or process optimization.

2

Create Model

Define your columns and chromatography system, then upload experimental data to calibrate the model.

Define your columns

Select among templates, or create your own custom columns

Build your system

Connect unit operations to mirror your actual chromatography system. Templates are of course also available.

Upload experimental data

Import your experimental results to calibrate the model. Multi data formats are supported.

3

Calibrate the model

Fit model parameters to experimental data. Typically, only 5-8 experiments are needed to build a well-fitted model. The calibration usually takes a few hours, so be patient.

4

Validate the model

Validate the model accuracy by performing an additional 1-3 experiments, and compare these unseen experiments with the simulation results. If the model fits, you are good to go! If not, repeat the calibration step with the new experiments included.

5

Use the model

Once you have validated your model, use it to simulate thousands of experiments in minutes.

Why Mechanistic Modeling?

Imagine being able to simulate any chromatography experiment you want. That is what mechanistic modeling enables. It is a digital twin for your entire downstream process lifecycle.

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Fewer experiments

Reduce the number of experiments and thus time and cost compared to traditional process development methodologies.

Increase process understanding

Provides full insight into process parameters, correlations, parameter sensitivies, and much more.

Quality by Design by Design

All of Efflux's modeling solutions are built to systematically promote, achieve, and follow Quality By Design (QbD) principles.

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Contract Modeling Service

Interested in the benefits of modeling but don't want to start modeling yourselves?

Team up with us, and we will do the modeling for you. That way, you can focus on what you do best.

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Ready to accelerate your chromatography development?

Join leading biopharma companies using Efflux to simulate downstream process development, scale up, and more.